Engineering Low-Fouling and pH-Degradable Capsules through the Assembly of Metal-Phenolic Networks

Y Ju; J Cui; M Müllner; T Suma; M Hu; F Caruso

Journal article

Engineering Low-Fouling and pH-Degradable Capsules through the Assembly of Metal-Phenolic Networks

Y Ju, J Cui, M Müllner, T Suma, M Hu, F Caruso

Biomacromolecules | Published : 2015

DOI: 10.1021/bm5017139

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Abstract

Metal-phenolic coordination chemistry provides a simple and rapid way to fabricate ultrathin films. Here, we report a facile strategy for the preparation of low-fouling and pH-degradable metal-phenolic network (MPN) capsules using a synthetic polyphenol derivative, poly(ethylene glycol) (PEG)-polyphenol, as a building block. PEG-MPN capsules exhibit reduced nonspecific protein adsorption and cell association compared with tannic acid (TA)-MPN capsules. In addition, they show faster disassembly at a biologically relevant pH (5) than TA-MPN capsules (80% in 5 h vs 30% in 10 days). PEG-MPN capsules combine both the low fouling properties of PEG and the advantages of the MPN-driven assembly proc..

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University of Melbourne Researchers

Yi David Ju Author

Frank Caruso Author

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

This work was conducted and funded by the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (Project Number CE140100036). This work was also supported by the Australian Research Council under the Australian Laureate Fellowship (F.C., FL120100030) and Super Science Fellowship (F.C., FS110200025) schemes. M.M. acknowledges The University of Melbourne for a McKenzie Fellowship. Deconvolution imaging was performed by Benjamin Hibbs at the Materials Characterisation and Fabrication Platform (MCFP) at The University of Melbourne. We thank Dr. Kristian Kempe, Dr. Huanli Sun, Dr. Julia Braunger, and Junling Guo for helpful discussions.